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The immunostaining for Tβ4 appeared granular or homogeneously diffuse, always restricted to the cytoplasm of positive cells; no nuclear reactivity was observed in this study.
The changes may be homogeneously diffuse, simulating a marrow-infiltrative tumour, or focal and patchy, simulating metastases.
Interestingly, CBP staining was faint and homogeneously diffuse throughout the nucleus in the MDA-MB-436 cells (Fig. 3A); while in the 436.1 cells, three or more bright, dot-like foci appeared in the nucleus, in addition to the diffuse nuclear staining (Fig. 3B,3C,3D).
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However, in another scenario (Figure 3b), if the dissolution rate of one reactant is higher than the other, the reactant with a higher dissolution rate would be dissolved into the molten salt first and then the dissolved reactant would coat on the reactant with a lower dissolution rate, as shown in situation B, rather than diffuse homogeneously into the reactant.
The labeling was no more observed in the subventricular zone but became diffuse, homogeneously distributed over the neuropil and formed a gradient across the cortical layers, from intense in the superficial layers to very low in the deepest layers (Fig. 8E–E″').
The marrow T1 signal intensity can be homogeneously decreased, but diffuse involvement can also be characterised by a heterogeneous decrease in T1 signal intensity, due to the presence of multiple tiny areas of marrow replacement, known as the variegated or 'salt-and-pepper' pattern[ 8].
MBD6 displayed a heterogeneous subnuclear localization in the cell population: in a quarter of the cells the protein overlapped with the chromocenters; in the remaining cells the protein diffused homogeneously within the nucleus (Figure 4B).
While N-surv was only scattered in some areas of AK, MD and WD cSCC, it was diffuse and homogeneously distributed in situ and in PD cSCC.
a Fat-suppressed T1-weighted image shows diffuse pancreatic swelling and homogeneously hypointense pancreas.
a Fat-suppressed T2-weighted image shows diffuse pancreatic enlargement and homogeneously hyperintense pancreatic parenchyma comparable to spleen.
All lesions were diffusely and homogeneously contrast-enhancing (no necrosis).
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