Sentence examples for homogeneous breast from inspiring English sources

This set-up mimics a homogeneous breast held in the measurement cup with a single lesion in which the contrast agent has accumulated.

Signal intensity (SInormal) and ADC of normal tissue were measured by placing ROIs in homogeneous breast parenchyma without enhancement in the centre of the contralateral breast, avoiding contamination by fatty tissue.

Two cDNAs (LIM kinase and BUB3), which are differentially-expressed in the present malignant library, have also been found to be differentially expressed in a subtracted library representing cDNAs expressed in a pathologically homogeneous breast carcinoma specimen subtracted with cDNA from 50 000 ductal-carcinoma- in-situ cells microdissected from the surrounding normal tissue (Liu, 2001).

Total RNA from microscopically confirmed homogeneous breast cancer tissue was isolated from approximately 500 mg of frozen specimen or from one flask of the HepG2 cell line, kindly provided by Dr N Harada [ 21], as a positive control and to generate standard curves.

Thus, while our analysis supports the view that this specific integrative epigenetic-transcriptomic landscape is fairly homogeneous in ER+ breast cancer, this does not by any means exclude the possibility that ER+ breast cancer is highly heterogeneous in relation to the correlative patterns of DNA methylation at distal regulatory elements and downstream gene expression.

The shift of TPH1 gene expression from the normal tightly-regulated in vivo pattern to a state of homogeneous overexpression in breast cancer cells was reminiscent of the general up-regulation of ER in estrogen-sensitive breast cancer cells [ 47, 48].

To the best of our knowledge, there are not previous studies which investigated a large and homogeneous cohort of breast cancer patients about the role of RANK expression in primary cancer cells in predicting bone metastatization.

To validate our results, we conducted subgroup analyses of the large and homogeneous group of breast cancer patients.

However, no effect was observed when analysing the large and rather homogeneous group of breast cancer patients.

Future studies to identify predictive gene sets within clinically homogeneous subgroups of breast cancer may further improve outcome prediction based on genetic signatures.

Prediction of pCR in the molecularly more homogeneous ER-negative breast cancer subpopulaton proved to be the most difficult classification challenge: the validation AUCs ranged from 0.34 to 0.62.