Tyrosine recombinases use a Holliday junction to break and rejoin single strands in pairs while serine recombinases introduce a DSB before strand exchange.
"At A.D.M., that was just too high up, not the working people," Ms. Holliday said, taking a break from making biscuits.
Although the same effect could be achieved by a coincident duplication and deletion, conversion events are believed to result from a different biological mechanism, namely DNA double-strand breaks or a double Holliday junction dissolution mechanism (Chen et al. 2007).
It is typically caused by DNA double-strand breaks or by a double Holliday junction dissolution mechanism [ 11].
Entamoeba has homologs of six of nine meiosis-specific genes, suggesting that it may be able to initiate double-strand breaks and promote interhomolog recombination and Holliday junction resolution with crossover interference.
Whereas tyrosine recombinases exchange DNA strands through a Holliday intermediate, serine recombinases such as Hin generate double-strand breaks in each recombining partner.
The current view suggests that WRN interacts with shelterin proteins to resolve G-quadruplex and Holliday junction structures in addition to aiding repair of DNA breaks during DNA synthesis [ 6, 7, 22].
First, it triggers resolution of double holliday junctions created through the repair of Spo11-induced double strand breaks, to produce reciprocal crossovers, thereby generating bivalent chromosomes [ 44].
Spicer did not condone all of the Earps' actions and criticized Virgil Earp's use of Wyatt and Holliday as deputies, but he concluded that no laws were broken.
Repair of DNA double-strand breaks via the RecBCD pathway leads to the formation of Holliday junctions.
