"holistic regulation" is a correct and usable phrase in written English.
It is typically used in the context of government policies or regulations that take into account the entire system or environment rather than individual components. Example: The government is implementing a new approach to environmental protection by focusing on holistic regulation that considers the interconnectedness of ecosystems and human activities.
Further, monitoring training supports holistic training regulations and is, therefore, important to enable optimal individual training adaptations [ 3]; hence, prevention or early detection of musculoskeletal injuries might be possible [ 4].
The EU Water Directors recently supported the proposal by the Commission to consider such a more holistic approach for regulation of chemicals in the aquatic environment in view of the WFD review [47] and an effect-based methods (EBM).
On the basis of successful efforts to reduce prevalence of V. parahaemolyticus infections in Japan (15 ), we suggest holistic approaches involving regulations and guidance on fishery products and food hygiene to decrease the incidence of these infections in China.
We therefore chose this plant to try to obtain a holistic view of GS regulation in a single plant.
From these considerations it is obvious that a holistic theory of transcriptional regulation has to include the relationships between these two logically distinct (digital-binary and analog-continuous) types of information and therefore has to distinguish them in the first place.
Recent work on flowering time regulators such as GI and APETALA1 have uncovered an intricate coupling of phase change and flowering time pathways (Yant et al. 2010; Huijser and Schmid 2011), indicating that a more holistic view of gene regulation is necessary to understand flowering time in plants.
Considering that gene expression is a complex interplay of hundreds of diverse factors, to facilitate a holistic understanding of gene regulation during stress response, it is imperative to generate a comprehensive picture taking into account both genetic as well as epigenetic factors, including histone chaperones.
The fact that miRNAs could act as cell proliferating factors in certain cancers and apoptotic factors in another has evoked the necessity of studying their cooperative functions in order to provide a holistic picture of miRNA regulations in cancer biology and pathogenesis.
When interpreting the findings it is important to take a comparative holistic approach whereby apparent down regulation of genes in fish fed one diet may in fact be the result of up regulation in fish fed the other dietary treatment and vice versa.
Analysis of whole genome-scale networks can provide a holistic view of all transcription regulations among and within different subnetworks and allows us to gain a more comprehensive understanding of regulation of cellular processes and events.
