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We have presented a holistic biomolecular reactions model that successfully recapitulates the dynamic phenomena of ASYN overexpression and oligomerization and predicts the biological system's behavior for a number of in-silico intervention scenarios not used for model calibration.
Therefore, comprehensive human metabolic models, which provide not only a list of reactions but also relationships between genes and proteins through reactions, are needed for holistic understanding of human metabolism through simulation and data integration.
The presumably high potential of a holistic design approach for complex biochemical reaction networks is exemplified here for the network of tryptophan biosynthesis from glucose, a system whose components have been investigated thoroughly before.
However, it is now possible to use this genomic data to reconstruct complete networks of biochemical reactions and produce more holistic mathematical models that may explain and predict their behavior.
The results of two empirical studies indicate that the holistic perception of online settings enhances emotional reactions and leads to desired behavioral outcomes.
A series of interconnected pathways is referred to as a biological network, which denotes a more holistic view on the entanglement of cellular reactions.
The major objective of the study is to analyze the holistic influences and the individual significance of the aforementioned reaction conditions on the defined MSR performance indices.
In this work, multi-scale analysis and strategy is explored to take a holistic view toward catalyst design perspective and elucidate impacts of designs at different scales to a catalytic reaction process performance.
It sounds quite holistic.
Very holistic.
The holistic practitioner came.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com