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This technique was used to examine the relationship between temporal activity patterns of component-related and envelope-related neural activity during holistic pitch perception.
However, once the distance between tone components becomes sufficiently large, the number of fibers that respond to multiple components would start to decrease, leading to a decline in the activity contributing to holistic pitch percepts.
Despite the recent discovery of primate auditory cortical neurons that appear to be selective for holistic pitch [6], there is no clear picture of how information converges within the auditory pathways that contribute to the response characteristics of these neurons.
Precise subjective reports of holistic pitch percepts are laborious to implement in animal subjects, but can be easily measured in humans by adjusting the frequency of a pure tone until it matches the apparent pitch of a stimulus sound.
For example, timbre, another holistic attribute of sounds, may be derived in part from integrative comparisons between envelope and fine-structural information over a larger region of the tonotopic map than is used for holistic pitch.
Humans and other mammals display highly similar holistic pitch percepts, assigning a low-frequency pitch to sounds that have spaced, tonal higher-frequency components, even when low-frequency components are absent (the missing fundamental) [4], [5].
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These results suggest a coding scheme for holistic pitches whereby limited regions of the tonotopic map (spectral places) carrying envelope- and component-related activity with similar timing patterns selectively provide a key source of neural pitch information.
To examine this process in more detail, stimuli made up of three pure tones whose components are individually resolved by the peripheral auditory system, but that nonetheless elicit a holistic, "missing fundamental" pitch percept, were played to human listeners.
Many models have since been proposed to account for the holistic nature of pitch percepts [3], focusing either on neural timing patterns or spatial patterns of neural activation extracted over the whole array of auditory frequencies.
Reliance on pitch chroma suggests the holistic listening mode, wherein one percept for the entire complex harmonic tone is generated.
Our finding that most of our subjects relied on the pitch chroma cue resembles the holistic listening mode of missing fundamentals13,15.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com