!!!The one way sensitivity analysis evaluated the risk ratio under various sensitivity measures while holding the specificity fixed.
Under the assumption that non-smokers are less likely to claim smoking, we conducted one-way sensitivity analyses to calculate the expected risk ratios of having a TJR associated with smoking under various sensitivity measures (i.e., 0.99, 0.95, 0.90, 0.80, 0.75, 0.70, 0.60 and 0.50), while holding the specificity constant.
Using simple assumptions (the median PSA among all 4556 men < 60 screened being 0.9 ng/ml and holding the specificity at this PSA level around 55%, as reported), and making a small change in false negatives, from 0 to 1, the corrected sensitivity drops to 80%.
Pre-treatment of BMSC with U0126 and SB 203580 in concentrations held low enough to maintain specificity of inhibition resulted in approximately a 50% decrease of IL-6 upon exposure to NGF or BDNF (Figure 7).
A previous study showed that the expression profile determined by strand-specific protocol was highly correlated with the ones by quantitative PCR and tilling array, providing high-quality sequencing data and holding the strand specificity [ 23].
To examine the effect of genotyping assay specificity, assay sensitivity was held unchanged and specificity was reduced from 0.95 to 0.90, 0.85 and 0.80.
Although this general rule regarding specificity holds true, it is an over-simplification, and the sequence recognition specificity of the CRISPR system is a topic of active investigation (Cho et al., 2014; Esvelt et al., 2013; Pattanayak et al., 2013; Ran et al., 2013b; Ren et al., 2013).
Also, next-generation IGRAs that incorporate new M. tuberculosis-specific antigens which significantly enhance diagnostic sensitivity without compromising specificity hold promise and should therefore be assessed in this population [33].
Some critical cases where ksp does not hold as a specificity index are classified for the first time.
Superresolved methods thanks to their high resolution and molecular specificity hold a great promise to play a pivotal role in the understanding of the next generation of self-assembled biomaterials.
