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The biosensor developed in the study can provide a cost-effective platform for NAT, thus holding potential for disease screening.
The presented method facilitates an inexpensive manufacturing technique of nanogaps as small as 12 nm, holding potential for the preparation molecular electronics devices.
Such interventions were among the technologies that the SENS roundtable group identified in 2000 as holding potential for reversing the frailties of aging.
Capacitance measurements were performed by the "sine+DC" method, in which a 1 kHz sinusoidal voltage command (30 mV peak-to-peak) was added to the −60 mV holding potential for the first and last 100 ms of each trace.
Oocytes were held at −90 mV (holding potential) for 360 ms, and a voltage step was then applied for 40 ms. Nine different voltage steps were applied to the oocyte (−120 mV, −60 mV, −40 mV, −30 mV, −20 mV, −10 mV, 0 mV, 10 mV, 40 mV), and are collectively referred to as a voltage train.
The holding potential for all recordings was −70 mV.
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Phrank also holds potential for helping doctors identify new genetic diseases, Bejerano told me.
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