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Only a dozen or so incidents have left their traces in the DNA of HIV strains around today.
HIV strains with multiple mutations in these amino acids are rare, suggesting that those strains struggle to survive.
HIV strains resistant to KP-1212 have not yet been isolated.
HIV strains resistant to other NRTIs (e.g. zidovudine, lamivudine, stavudine, abacavir, etc).
SFT was found to inhibit replication of all tested HIV strains.
SP-D inhibited the infectivity of HIV strains at both pH values of 7.4 and 5.0 in a concentration dependent manner.
Serial dose escalation was used in attempts to select for HIV strains resistant to MDH-1-38 aNS1040040.
The emergence of multidrug resistance and transmission of drug-resistant HIV strains limit the clinical efficacy of current therapy.
Thus, there emerges an urgency of developing a novel anti-retroviral agent that combat resistant HIV strains.
Importantly, the immunized mouse sera were able to neutralize HIV strains including those belonging to clades B and C.
Human immunodeficiency virus (HIV) strains containing both reverse transcriptase (RT) mutations are resistant to all of the approved NNRTI drugs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com