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The early stages of the HIV replication cycle in an infected cell are shown.
Scheller, C. et al. CpG oligodeoxynucleotides activate HIV replication in latently infected human T cells.
More recently, LEDGINs were found to affect late stage HIV replication as well.
Aguiar, R.S., Lovsin, N., Tanuri, A. & Peterlin, B.M. Vpr.A3A chimera inhibits HIV replication.
IL-27 is known to inhibit HIV replication via induction of IFN-dependent APOBEC proteins5.
Bushman, F. D. et al. Host cell factors in HIV replication: meta-analysis of genome-wide studies.
Christ, F. et al. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.
Highly active anti-retroviral therapy (HAART) effectively reduces HIV replication but does not completely hinder it.
Antiretrovirals suppress HIV replication and prevent mother-to-child-transmission of HIV (PMTCT).
The compounds also inhibited HIV replication with potencies comparable with their integrase inhibitory potencies.
These modifications led to the identification of oxindoles with low nanomolar potency for inhibiting HIV replication.
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CEO of Professional Science Editing for Scientists @ prosciediting.com