Apparently unwilling to rest on his laurels after garnering wide acclaim for his remarkably accurate predictions for the U.S. Presidential election (aka the "Super Bowl" of politics) at his Five Thirty Eight blog at The New York Times, statistician Nate Silver has unleashed his mind on a decidedly more (ahem) hard hitting matter: the actual Super Bowl.
As for the N.L., a pitcher's ability to hit matters at least a little bit.
The shortage of "greatest hits" mattered not at all.
In the other, as if proclaiming that only hits matter, he wasted time as a disc jockey, playing Journey, Nirvana and Michael Jackson.
On the Internet, hits matter more than profits.
Iterative rounds of structure-activity relationship (SAR) chemistry on representatives of the initial screening hit matter, in vitro profiling and X-ray crystallography resulted in the discovery of 4-chloro-1- 4-piperidyl -N-[5- 2-pyridyl -1H-pyrazol-4-yl]pyrazole-3-carboxamide (BDP5290; Figure 1A) as an MRCK inhibitor with excellent potency and selectivity profiles.
But most commentators believe that the financial hit matters less to the Kremlin than its international credibility.
Batting average was, for a long time, one of the key components in how teams judged players: hitting.300 mattered not just to a hitter's pride but also to his wallet.
Even more than MTV, which sometimes tries to teach the kids a bit of history (by letting current rappers choose their favorite older song, for instance), Fuse's programming exists in a perpetual pop present, in which only a handful of hits matter.
We suggest that such protein binding site maps will be useful for building further understanding of the relationship between small molecules and complex biological systems; this approach is potentially applicable to the discovery of hit matter for novel biological targets, for predicting and rationalizing ligand polypharmacology and for predicting protein function [3, 4].
