Sentence examples for hits active from inspiring English sources
In this study, we have shown that a stringent promiscuity filter that first selects hits active in <20% of the projects (filter F2) and subsequently retains compounds with activity in <20% of the assays within a project (filter F3) is necessary to enrich for hits with specific biological activities.
In addition, finding hits active in whole cells provides no information on the likely target, which is important to enable drug optimization.
Unlike some viral or transposon-based insertional mutagens, the DNA alkylating agent ENU can introduce a high rate of point mutations into the genome, irrespective of whether it hits active genes, inactive genes, or intergenic regions [ 17, 18].
The best pharmacophore model was further validated through enrichment calculations and it shows strong predictive power with a high performance in identifying active ligands from the total hits (actives + decoys).
Closer inspection of the correlation coefficients values (Table 4) of the 3DZD for the actives showed that their values were fairly close with difference of 0.0122 between the closest inactive retrieved (0.0995) and the first hit (active) ranked at 245 (0.98245.
He is 10th in hits among active players, but only two players ahead of him are younger: his teammates Jeter (2,688) and Rodriguez (2,483).
These compounds with high estimated activity were analyzed for drug like properties and docking studies were performed, to study the interaction between new hits and active site.
After that, if the tip of the planar reservoir hits an active fault or a crack, hot water is ejected and a phreatic eruption occurs.
In recent years, more than 20,000 hits phenotypically active against P. falciparum, one of the major malaria causing agents, were disclosed from three independent HTS campaigns [1 3].
When a photon hits the active area of a microcell, an ionization cascade ("avalanche") can be triggered that results in a largely amplified current peak.
Just how big a hit do active parents take?
