Sentence examples for hitherto undefined from inspiring English sources

During a migraine attack occurring from several minutes to hours after the end of CGRP infusion, it is possible that exogenous CGRP (likewise many other vasodilator substances) targets a hitherto undefined central site that eventually results in sensory nerve activation and the release of endogenous CGRP.

Therefore, our data indicate that TPH2B is an isoform that contributes to the brain 5-HT binsynthesis in a hitherto undefined manner.

On the other hand our data also suggest that the effect of SYT-SSX is not limited to methylation changes at the H19 ICR but rather affects additional, hitherto undefined, regulatory mechanisms at the H19/IGF2 locus.

Also, a hitherto undefined substrate of NE in the nucleus promotes leukemogenesis in an acute myeloid leukemia mouse model 120.

Here we describe the current status of clinical modalities, both specifically designed to target Tregs and those drugs for which their immunomodulatory function may constitute a hitherto undefined mode of action.

Hypoxia is involved in lung development, and KLEIP, a hypoxia-inducible protein that belongs to the functionally diverse family of kelch proteins, is thought to play an important, hitherto undefined, role in prenatal development.

However, how these compensatory mechanisms are activated has remained hitherto largely undefined.

The hitherto undescribed and as yet, undefined specific immune characteristics that have allowed persistence and replication of HPV activity at the cervical site are also likely to play a major role in the high prevalence of HPV at the other mucosal sites.

Possibilities include autocrine signalling, effects of undefined interacting or co-operating proteins and the presence of hitherto undetected mutational events.

Hitherto insipid, Arsenal awoke.

which basically remains undefined.