In line with this assertion, even in Japan where GMA is most widely used, the popular opinion is that patients' disease activity level, location and duration of disease, the extent of mucosal damage, hitherto response to conventional medications, and other known causes of refractoriness like cytomegalovirus infection should be taken into consideration to select patients for GMA therapy [ 16- 18].
Neurodegeneration with axonal degeneration and loss of NMJs, considered a primary event in ALS pathogenesis, may underlay the hitherto limited response of animal models or human trials to anti-inflammatory therapies.
The RNA-Seq analysis, in combination with microarray and proteomics approaches, highlights hitherto unreported cellular responses to HCV infection at the gene level, adding to the recently published data by Walters et al. 31 The RNA-Seq approach, based on new technological advances in massively parallel sequencing, has a number of advantages over conventional microarray techniques.
The feasibility and diagnostic utility of this approach using RD-1 antigen-specific ELISPOT responses has hitherto not been evaluated.
Boundary conditions and thermal environment affect the low velocity impact response of GLARE, hitherto not reported in the open literature.
This speed introduces a range of dynamic responses that have hitherto not been observed in generic high-speed trains.
The quick response (QR) code has hitherto proven uninspiring.
Currently, we are using existing tumour markers to follow dynamic fold changes in biomarker levels in response to therapy, a hitherto little explored approach.
The goals of the analysis were to: (i) characterize the diversity of response and determine how it mapped to clinical subtypes, (ii) identify factors that controlled the magnitude and duration of ligand response, and (iii) generate a simple means to look up and compare ligand-response data that have hitherto been unavailable or scattered across the literature.
The first-order shear deformable Mindlin plate theory hitherto considered was adequate for determining responses to dynamic loads.
The relation between microvascular PVAT and microvascular vasomotor responses in vivo was hitherto unknown.
