Hitherto, large-scale investigations have not been sufficiently performed to characterize the oral fungal carriage rate, species prevalence and antifungal susceptibility among HIV-infected individuals in China.
Therefore these and other difficult splits were examined by phylogenomic analysis of the hitherto largest sequence alignment.
While awaiting large clinical trials that address this issue, we conducted the hitherto largest combined population-based case-control and cohort study, taking advantage of high-quality Danish health registries and using extensive adjustment for potential confounders.
This study, which includes the hitherto largest taxon sampling for subfamily Lobelioideae, highlights the need for a broad phylogenetic framework for testing assumptions about morphological development in general, and convergent evolution in particular.
The hitherto largest dataset in canine CNV discovery was assessed, 351 dogs from 30 different breeds, enabling identification of novel CNVs and a thorough characterisation of breed-specific CNVs.
In this hitherto largest case-control study on statin use and risk of pneumonia, current statin use was associated with a reduced risk of hospitalization for community-acquired pneumonia.
Since large clinical trials that address this issue are still lacking [ 26], we conducted the hitherto largest population-based case-control study on statin use and risk of pneumonia, taking advantage of new high-quality Danish data to better control for confounders.
In the evaluation of the hitherto largest cohort of almost 7000 patients with end stage liver disease (listed as status 2A, 2B, and also status 3) showed that the CTP was slightly better, but not significantly different than MELD score in predicting 3-month survival.
What has been described above as a theoretical scenario has actually been empirically demonstrated meanwhile: The GERAC study (German acupuncture trial), the hitherto largest acupuncture trial, tested real acupuncture versus minimal acupuncture as a control procedure, versus pharmacological prophylaxis in migraine patients as an active treatment.
In the hitherto largest study of 332 tumours, all N-negative, cyclin B1 was associated with poor prognosis but not in multivariate analysis including Ki67 (Rudolph et al, 2003), and when 273 tumours with only surgery and postoperative radiation were analysed, cyclin B1 was prognostic only in premenopausal patients (Kühling et al, 2003).
The governance of complex processes, such as energy transitions, large infrastructural projects or comprehensive spatial planning issues, has hitherto largely been approached along two lines.
