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"Hitherto it is questionable if all the mechanical inventions yet made have lightened the day's toil of any human being," John Stuart Mill wrote in the "Principles of Political Economy" (1848), and the precept holds for recent innovations, too.
Hitherto, it is largely unknown how this balance is regulated.
However, hitherto it is unknown whether hsf-1 activity is directly regulated by the IIS pathway.
Hitherto, it is unclear whether degeneration of RGC axons precedes degeneration of RGC somata during glaucoma.
Hitherto, it is not yet clear whether miRNA can regulate necrosis in cardiomyocyte.
Most importantly, hitherto it is unknown whether IIS reduction late in life, the stage at which most human neurodegenerative disorders onset, could provide protection from proteotoxicity.
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Hitherto it's been a hidden history, a neglected history, even though its contained in some other archives now we have a specialised archive that is not only going to showcase and preserve this collection but encourage people in the community to preserve and collect things, be it documents or oral accounts, that can contribute to this story.
(Hitherto it's felt merely like heated-up leftovers from the spring).
However, hitherto it was neither theoretically predicted nor observed that these pulsations would affect their X-ray emission.
Hitherto, it was believed that Jason Statham's bad guy Deckard Shaw would be the main villain in the upcoming film - he is, however, still set to appear.
Hitherto, it was unclear whether or not these spellers rely on eye movements.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com