Sentence examples for hit mechanism from inspiring English sources

Recent studies suggest a "second hit" mechanism resulting in amplification of mutant RET.

A 'two hit' mechanism has been proposed to drive NASH pathogenesis.

This 'two hit' mechanism was first hypothesised by Knudson (Knudson, 1976) and later substantiated following cloning of RB1 (Friend et al, 1986).

Replication fork collapse and checkpoint abrogation by Chk1 inhibitors induces potentially lethal DNA damage killing gemcitabine treated p53-mutant cancer cells by a "double hit" mechanism.

Through the study of hereditary and sporadic retinoblastomas, Knudson postulated a two hit mechanism which included the process of growth and differentiation in normal tissues (Knudson, 1971).

Furthermore, as none of the tumors with MLH1 deficiency showed MLH1 methylation, methylation is not a "second hit" mechanism in biallelic inactivation of MLH1.

Researchers are faced with genetic heterogeneity, reduced penetrance, unmasking of recessive alleles, "second hit" mechanisms, pleiotropy, epigenetic mechanisms, and possible environmental mediators.

In fact, membrane vulnerability may be the other factor of the "two-hit" mechanism.

Furthermore, the first quantitative evidence for the "two-hit" mechanism in this disease was documented.

These two factors may explain the previously suggested "two-hit" mechanism in this disease [23].

We have for the first time quantitatively demonstrated the existence of the "two-hit" mechanism in this disease.