The number of hit interactions increased from top 1 to 10 (Fig. 8).
Fig. 8 The number of accumulated hit interactions from top 1 to 10.
It might be argued that the two events of infection and asphyxia act independently but additively to affect early newborn death rather than through a double-hit interaction.
It is unclear why not all patients with NF1 develop proteinuria and FSGS, but few explanations may be variation in point of mutation in NF gene, variation in nephron numbers, requirement for a second hit and interaction with environmental risk factors.
The biggest hit was "Interactions," by David Birchfield.
How R U," or "Insnt MssGng Is so kool!" When the urge hits for interaction, get positively medieval: write a letter.
To further optimize these biologically validated virtual hits, molecular interaction fields (MIFs) for the dimerization of TLR2 and TLR1 were developed.
For 25 out of the 33 hits, genetic interaction data were available.
Hits retaining interactions with the common amino acids of GSK-3β binding site were taken to represent potential leads.
Of note, the requirement that two hits share an interaction substantially reduces the number of edge hits compared to node hits.
Double click the name of the top hit 'cytokine cytokine receptor interaction' to visualize the expression profiles of its 22 genes.
