Besides its architecture, Frederick also takes pride in its Civil War history, with markers and signs of major events dotting the town and outskirts.
Subsequently we simultaneously adjusted the estimates for a range of personal characteristics, indicators of medical history, and markers of general health.
This has led to the idea that statistical models based on multiple predictors (PSA, age, family history, other markers) might be used to predict biopsy outcomes and hence aid biopsy decisions for individual patients.
However, it would be useful if, besides family history, histopathological markers could also be used to distinguish patients and families likely to carry a BRCA1/ 2 germline mutation from mutation-negative families and breast cancer patients in general.
Besides family history, histopathological markers could also be useful in distinguishing patients and families likely to carry a BRCA1/2 germline mutation from mutation-negative families and breast cancer patients in general.
Rather than commemorate a famous person who had stood there, or an event that had shaped history, the marker honored the role of dissent in the functioning of a "healthy democracy".
It's a subtle warning from history, a marker of a failed previous coup the Royals Business Park was a short-lived project stopped in its tracks by the global economic downturn.
This, together with the expense of resequencing, makes it natural to start with cases, perhaps supplemented by family history and marker data.
We now consider how selective sequencing enhances the detection of disease-related variants, and how incorporation of family history and marker sharing can further enrich the detection sample.
We show how case status, family history, and marker sharing enrich the discovery set by increments that are multiplicative with penetrance, enabling the preferential discovery of high-penetrance variants.
