Large FST statistics imply divergent selection for alternate alleles within different breeds suggesting that there may be several mutations in NBEA that have been strongly historically selected in some breeds and that are currently under selection in others.
In patients with asthma, macrolides have been reported to reduce airway hyperresponsiveness and improve pulmonary function, and have historically been selected for their "steroid-sparing" effect.
This often raises serious concerns, because transgenic (TG) or knockout (or knockin, KI) mice are generated in strains that have historically been selected for the ease and convenience of generating the TG or knockout strain, rather than phenotypic characterization of the mutation itself.
Historically, to select for transgenic animals with minimal effort, rescue of mutants that displayed phenotypes such as temperature-sensitive embryonic and larval lethality (pha-1 (e2123 ); Granato et al. 1994), or defective movement and inability to enter a stress-resistant dauer stage (unc-119 (ed3 ); Maduro and Pilgrim 1995; Praitis et al. 2001), were used as transformation markers.
In 2014, The Big Lebowski was deemed "culturally, historically, or aesthetically significant" and selected for preservation in the National Film Registry.
Each year, 25 films that are deemed "culturally, historically or aesthetically" significant are selected for preservation by the United States National Film Preservation Board and added to the National Film Registry at the Library of Congress.
Four forest fringed historically malaria endemic villages were selected for the study.
Variants that allow LCT expression after weaning are strongly selected for in populations that historically relied on animal husbandry (Tishkoff et al. 2007).
In 2002, Beauty and the Beast was deemed "culturally, historically, or aesthetically significant" by the Library of Congress and selected for preservation in the National Film Registry.
In 2008, The Terminator was deemed "culturally, historically, or aesthetically significant" by the Library of Congress and selected for preservation in the United States National Film Registry.
