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Historically, effective systemic treatment options have not been available for patients with unresectable advanced disease.
One difficulty facing those concerned about a growing gap between the United States and Japan in terms of capital investment is how to match the historically effective style of the Pentagon agency in supporting leading-edge research.
While historically effective, the use of bioengineering works is currently limited in France but still widely used alongside "hard" structural measures in other European alpine countries such as Austria, Italy, and Switzerland (e.g. Evette et al., 2009).
Prompted by the civil rights movement, the Voting Rights Act is commonly hailed as one of the nation's most historically effective civil rights statutes.
Next week marks the 48th anniversary of the passage of one of the nation's most historically effective civil rights statutes, the monumental Voting Rights Act of 1965 (VRA).
Historically, effective resistance to excessive Islamization in Muslim-majority countries has often been headed by the military, as champions of secularism.
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The demonstration of adverse health effects has historically preceded effective pollution control measures.
Chicago Department of Aviation officers, who have "historically been effective in getting customers to voluntarily comply," then arrived on the scene, the report said.
Democrats say that people who did exceptionally well over the last few years and are now paying historically low effective tax rates should pay a little more.
Purpose: We report a patient with severe multi-organ dysfunction of unknown origin who presented with bilateral orbital and chorioretinal manifestations that led to the diagnosis of Erdheim-Chester Disease (ECD).Observations: ECD is a rare, histiocytic, proliferative disorder characterized by multi-systemic organ involvement that has historically lacked effective therapy.
The invariance likely results from either a recent selective sweep, a recent origin for modern Homo sapiens, recurrent male population bottlenecks, or historically small effective male population sizes.
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