In December a Polish foundation brought schoolchildren from Poland, Germany, the West Bank and Israel together to re-enact historical trials, including Nuremberg, as part of a project about international justice.Despite prejudice and tragedy in Poland's past, a remarkable revival of Jewish life and culture is now under way, including an annual music festival in Cracow, near Auschwitz.
When planning a new trial, information on the variance of the endpoint is usually available from historical trials.
Furthermore, the constancy assumption (that superiority shown in historical trials still applies today) may not apply due to advances in medical care in the intervening years [28].
Comparative noninferiority trials to develop alternatives to warfarin must include warfarin management that is at least as good as that provided in historical trials.
Historical trials using adjuvant hormonal therapy have been limited due to difficulties in clinical staging, as well as toxicities attributed to the formulations used.
In agreement with historical trials, patients with less severe forms of septic shock (lower lactate concentrations at baseline) appear to benefit more from AVP in comparison with patients with more severe forms.
Matching performance was validated on a reference set of 169 historical trial-patient enrollment decisions, and workload, precision, recall, negative predictive value (NPV) and specificity were calculated.
As such, the applicability of historical trials to current day practice may not be valid.
The new RECIST criteria do not allow for the comparison of historical trials using WHO and current trials using RECIST.
