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Castration-resistant prostate cancer (CRPC) has retained a guarded prognosis, with historical survival estimates of 18 to 24 months.
These data compare well with historical survival figures.
All of these results are higher than historical survival times of less than eight months.
Finally, combined chemoradiation with fluorouracil and mitomycin in 34 patients seemed to be beneficial compared to historical survival data [ 30].
This is higher than historical survival and is similar to survival with systemic chemotherapy and TACE therapy.
Thus it is unclear if these findings can be extrapolated to the burn population, with historical survival rates of less than 30% [ 1- 3, 11].
Similar(48)
Survival outcomes were better than the historical median survival of 7 months and independent of the patients' objective response [ 58].
This treatment regimen yielded stable disease for more than 2 years in a patient with advanced pancreatic cancer, which is a significant improvement compared to the historical median survival of 6 12 months in this patient population [ 18, 19].
The historical median survival for those patients with common tumours with tumour-specific therapy would be expected to be greater than that documented for this population (Hurwitz et al, 2004; Robert et al, 2006).
These outcomes were significantly better than historical controls, with survival significantly exceeding the survival expectations of Curran's recursive partitioning analysis (P < 0.0001) and the EORTC 26981/22981-NCIC CE3 Phase III randomized trial (P = 0.008).
Acknowledging the limitations of historical comparisons, STS-201 survivals compare favourably with survivals reported for patients after failure of second-line ifosfamide [ 15, 16] using the correspondent eligibility criteria as in STS-201 and for patients who received DAC [ 17] or ETO [ 30] after the failure on standard CT.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com