We begin in Section 1 by discussing George Berkeley's Towards a New Theory of Vision (1709), the historical locus classicus of action-based theories of perception, and one of the most influential texts on vision ever written.
Mutations were allowed in all historical generations for all loci with a mutation rate of 1.25×10−3 per locus, per generation, and per animal.
The alternative ancestral gene order is composed of many distinct haplotypes as expected given historical recombination among marker loci.
Within a closed breeding population, the extent of LD is affected by the distance between the loci and historical effective population size [ 9].
The increasing use of nuclear DNA (nDNA) sequences in phylogeographic studies, in combination with sequence data from a haploid organellar locus, has been driven by the considerable improvements in strength and accuracy of historical inference that multi-locus analyses can provide [ 1].
The spot on which you stand can be the locus of historical contests yet still seem comfortably nestled in a pastoral, courtly or regal setting.
These findings have been interpreted as the result of a historical restriction of S-locus diversity that occurred approximately 15 MYA [ 7] in a common ancestor of Physalis and Witheringia that is not shared with Solanum or other sampled genera of Solanceae [ 3, 7, 13].
Furthermore, mitochondrial DNA is more likely than many single nuclear sequence loci to reflect historical population affinities given the former's smaller effective population size.
Significant linkage disequilibrium was observed for 14 of the 28 locus by locus comparisons in the modern data set (corrected p < 0.0042), but for none of the loci in the historical data, when corrected for multiple testing.
If historical selection pressures on these loci were related to female maturation, changes in gene regulation may therefore have played an important role in the evolution of these traits in humans.
