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Relationships between enzyme estimates (EE) and histologic measurements of infarct size (HIS) were analyzed in 14 conscious dogs with permanent occlusion of the circumflex coronary artery.
The histologic measurements reported here point to a loss of approximately 40% more islet volume in Myd88−/− animals as compared to WT controls on the same C57Bl/6 background.
This study examines the predictive value of simple quantitative renal histologic measurements in a large cohort with extended follow-up.
Twelve out of the 22 hESC treated VFs were prepared for histologic measurements at time point of three months.
For the histologic measurements, each single value was included when differences between the various groups were estimated.
Most researchers have either studied the small animals such as rats, cats, or rabbits [ 2, 6, 10, 20– 22], for relatively long periods of 6 12 weeks [ 4, 5], or carried out gross observational studies with no histologic measurements [ 1, 2, 9, 19, 23].
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The objective of this study was to correlate preoperative radiologic estimation with postoperative histologic measurement of steatosis.
In order to make ultrasound data correspond more closely to histologic measurement, the largest cross-section planes were used in both techniques.
The secondary and tertiary outcomes included histologic change and measurements of biologically relevant markers, including COX-1 and − 2 mRNA, prostanoid levels, and methylation of tumor suppressor genes p16, APC, and E-cadherin.
For each histologic section, histomorphometric measurements were made 3 times and a mean value was obtained.
The dGEMRIC index has been validated against histologic and biochemical measurements of glycosaminoglycan content in clinical studies [ 42]. dGEMRIC has potential as a non-invasive technique for monitoring the glycosaminoglycan content of cartilage after repair by various techniques [ 43].
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