The most recognized histologic manifestation of common variable immunodeficiency is a paucity of plasma cells in gut biopsies.
Phosphorylated SFK expression is a common and specific histologic manifestation of bladder cancer [ 32].
The diagnosis of anti-GBM GN typically requires the demonstration of serum anti-GBM antibodies together with the typical histologic manifestation of anti-GBM-GN including intense linear IgG staining along the GBM.
We then documented that long-term treatment of male BXSB mice with an anti-IFNAR antibody of mouse origin reduced serologic, cellular and histologic disease manifestations and extended survival, suggesting that disease acceleration by the Tlr7 gene duplication in this model is mediated by type I IFN signaling.
Given this overlap in histologic characteristics and their manifestations in T2-weighted MRI, early reliance on calculated T2 measurements to differentiate lesions did not prove satisfactory.
In this chapter we present a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome.
While the early appearance of ARPKD is typically clearly dominated by renal manifestations and associated co-morbidities, histologic liver involvement is present in every ARPKD patient from early embryonic development on, reflected by the disease term "Polycystic Kidney and Hepatic Disease 1 (PKHD1)".
This review will focus on the renal manifestations of amyloidosis including pathophysiologic mechanisms, histologic features, protein identification and morphologic and clinical characteristics of common and rare forms of amyloidosis.
With the exception of macrophage infiltrates, therefore, the composition and extent of the cellular infiltrate may not be related to clinical manifestations, in line with observations of histologic synovitis in the absence of clinical joint involvement [ 48].
Cutaneous manifestations are confirmed by histology.
We searched for histologic, immunologic, and molecular evidence of B. burgdorferi infection in patients with cutaneous manifestations suggestive of Lyme disease in Mexico.
