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All patients received intra-operatively, during the anhepatic phase, at least two HIP units (range 2-10 units), each containing at least 4,500 IU anti-HBs antibodies.
Anti-HBs concentrations measured in 15 HIP units at the time of donation and again at transfusion are presented in Figure 4.
We observed pronounced inter- as well as intra-individual variability in anti-HBs titers under HIP treatment, which apparently related to variability in anti-HBs concentrations in the administered HIP units.
Findings were inconclusive in one review [ 97] and no significant differences were found in four reviews [ 79, 81, 101, 106], while one review [ 103] found a significant difference in the number of patients being discharged home when they were cared for at a stroke unit (based on three trials) but not when they were treated in hip units or geriatric units.
To evaluate whether plasmapheresis and/or storage at -80°C for 4-24 months would lead to a decrease of anti-HBs concentrations, we determined anti-HBs levels in 15 HIP units at the time of donation (in the plasma) and again at the time of transfusion (after freezing for 4-24 months for quarantine and thawing to room temperature before transfusion).
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We show through simulation that the proposed network can achieve the desired multi-functionality, even though it relies on hip unit generators to recruit appropriately timed knee extensor motoneuron activity, including a delay relative to hip activation in rostral scratch.
In multi-component interventions like a hip unit, one single active part of the intervention can normally not be identified.
The content of the hip unit intervention is described in detail in the electronic handbook library (see section Intervention above).
Our study differs in certain ways from other ongoing hip unit trials, for instance the Trondheim Hip Fracture Trial, with whom we are collaborating [ 53].
There is now a growing body of evidence supporting this approach [ 16, 17] and recently evidence-based guidelines as for treating hip fracture patients have been developed,[ 18] although context and organisation of so-called hip-units differs widely [ 19].
This would help hip fracture units decide on whether or not to adopt this protocol in light of the data discrepancies above and the impact this may have on BPT revenue.
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