But the overpowering smell of fresh paint inside hints of activity soon to come.
Another value of these technologies is that they can help the military monitor a broad area for hints of activity, and then zoom in for a detailed picture of a potential target.
The clinical data are just slowly maturing and hints of activity are seen in the BRCA-mutation cancers and triple negative breast cancer (TNBC).
Response rates are difficult to interpret in phase I studies where they can be only considered as complementary observational data looking for hints of activity.
These are vital, for example to provide hints of activity of new agents in very rare cancers, which could be tested within industry-sponsored trials in case of a positive result from early low-cost studies.
Furthermore, for the era of cytotoxic chemotherapy, several schedules of administration were concurrently examined in different phase I trials, detailed pharmacokinetics studies were performed, and the recommended dose and schedule was largely based on an analysis of the safety profiles, pharmacokinetics considerations, and preliminary hints of activity.
In addition, screening of new drugs in rare cancers is by definition less likely to happen, since phase I studies will privilege frequent cancers (more likely to be enrolled in comparison to any single rare cancer in any phase I study), and hints of activity from the phase I setting will be therefore lacking in rare cancers.
Listen for hints of activity from your parents' or siblings' bedroom.
Maybe I can hear the distant sound of a badly-tuned radio or the feint echo of young laughter under the virtual tide's hissing swell, a just-audible hint of activity on the edge of the cyber sea.
Hint of activity was apparent only with low-dose NGR-hTNF.
