These expression data therefore hinted at functions for CDPK1 in noninvasive stages, which we confirmed by knocking down cdpk1 expression in a sexual stage specific manner.
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Experimental evidence suggests that different functions may differ by orders of magnitude in the numbers of proteins that perform them [13], [14], [35], hinting that protein functions may differ in their designability just like structures do.
On the other hand, a number of orthologs were found to have significant disparity in their expression profiles, hinting at novel functions, divergent regulation, or new ortholog relationships.
These RM boxes form CpG islands and lie a short distance upstream of a conserved promoter region thus hinting towards regulatory functions.
The figure clearly shows an extensive patch of conserved residues spanning the surface hinting to a function of these residues in signal sensing or the activation mechanism.
Imp2's central domain is also differentially phosphorylated throughout the cell cycle (unpublished data), hinting that Imp2 function may also be regulated via phosphorylation.
The enrichment of structured RNA elements could be interpreted as hinting at a function of long unspliced regions in specific binding with proteins.
IpsA was chosen as target for further studies from a set of mutants strains as a Δ ipsA mutant displayed a drastically altered cell morphology hinting towards a function in the control of cell wall biosynthesis.
In neurons, at a subcellular level, all three proteins were found to be mainly cytoplasmic with minor staining in the nucleus and nucleolus (33, 35), and within the cytoplasm, all three could be found in association with ribosomes by immuno-EM, again hinting at similar function (33).
Homology modelling has shown that hydra XPA is likely to attain a structure very similar to human XPA in the folded state, further hinting that hydra XPA functions like other XPA proteins.
