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In April, another team told a medical meeting that its experiments in gene therapy for Parkinson's, which delivered a different gene to a different part of the brain, also appeared safe and gave a preliminary hint of benefit.
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There are also hints of benefit from vitamin K, an essential nutrient found in cruciferous vegetables (broccoli, kale, cabbage and the like), which are good for health in general (unless you take blood thinners).
Larry Biegelsen, the analyst who covers Abbott for Wells Fargo, has said that he thinks TriCor will fail in Accord too, although there may again be some hints of benefit.
Or at least a reward for a favor performed, carrying with it delicious hints of benefits to flow from future positive reviews.
The hints of benefits from MB suggest that MB might lead to lifespan and anti-aging benefits using other doses or alternate dosage schedules or both.
Although there was a significant benefit in this experiment, there was no hint of a benefit in Experiment 6, which was an exact replication except that the target prevalence was increased from 25% (Experiment 5) to 50% (Experiment 6).
While NICE makes a recommendation regarding reimbursement based on the (combined) appraisal of clinical and cost-effectiveness, G-BA/IQWiG quantify the additional benefit and its results certainty (e.g. proof, indication, or hint of additional benefit).
"We don't think there is a hint of a benefit," he said.
Still, it would have been nice to see a hint of a benefit for checkups in this analysis, given how much effort and time is invested in screening.
An early hint of no benefit to the heart came from a 2001 University of Pennsylvania study of 30 healthy men, which found that at doses of 200 to 2,000 I.U.'s, vitamin E did not prevent oxidation of blood fats that can damage arteries.
Only the sickest kids showed a hint of a benefit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com