On nucleotide binding, the active site pocket opens up and this opening is most likely transmitted by a hinge-like movement of the B204 helix α1 around the α1-β2 loop.
Crystallized in an inward open conformation the structure identifies a hinge-like movement within the C-terminal half of the transporter that facilitates opening of an intracellular gate controlling access to a central peptide-binding site.
Most dryers built in the last 20 years have hinge-like clips on the rear, and snaplock fasteners under the top to make removing the top easier.
In this way, the base of the inner pillar cell would have a hinge-like action at the point of contact with the bony spiral lamina.
Comparing the structures of the free enzyme and the complex in this region suggests that there is a hinge-like motion of the loop on inhibitor binding, reflected in the fact that the displacement is at a maximum at the tip of the loop, with its local conformation being largely unaffected.
Because the humerus has a hinge-like shoulder joint, the animal could only have swung it up and down, with little side-to-side maneuverability, the team concludes in the 2 April issue of Science.
The later relies on a hinge-like movement of the N- and C-lobes to adopt an open or closed conformation, consequently, determining the accessibility of the active site and substrate specificity.
From the extensive interactions within the heterodimer revealed here, it seems more likely that the relative angles between the rigid heterodimers, and between the heterodimers and the membrane, have to change for curvature formation, rather than the process being based on a hinge-like movement within the heterodimer.
From nucleotide-dependent CD-spectroscopy data of NBD94 and its C-terminal truncated form NBD941 550 it was also concluded that a hinge-like region in the C-terminal region of NBD94 may mediate the nucleotide-binding with further down stream events [27].
A new study published in BMC Biology reveals surprising tolerance to helix-disrupting changes in a region previously thought crucial for translocation, and suggests roles for two hinge-like segments of the bridge helix in coordinating modules that move during the nucleotide-addition cycle.
