Furthermore, those broadly neutralization antibodies directed against the HIV-1 MPER exploit the tandem joint architecture involving helix capping, thereby disrupting hinge function.
Possible interactions between hinge residues 52 and 277, or among 53, 135, 170, 186, 265, and 276 required for hinge function were discovered by sequence analysis to identify compensatory mutations.
The results of MARS analysis include an intercept value, hinge function and products of two or more hinge functions to account for the interplay between variables.
Crucially, our characterization of the dimerization process provides an essential basis for exploring more sophisticated aspects of hinge function, namely hinges' possible involvement in DNA entrapment.
We developed models using the linear, quadratic, and hinge functions, which were considered as the best combination to avoid the problem of over-fitting [68], [70].
To investigate whether cohesin's hinge functions as a possible DNA entry gate, we solved the crystal structure of the hinge from Mus musculus, which like its bacterial counterpart is characterized by a pseudo symmetric heterodimeric torus containing a small channel that is positively charged.
The standard hinge loss function is not differentiable everywhere, but here we can use quadratic hinge loss as below instead to make use of gradient-based optimization methods, e.g., LBFGS [6].
To train the classifier, a supervised learning algorithm is devised to minimize the hinge loss function under the new architecture.
where ℓ is a hinge loss function ℓ=max 0,ℓ n ).
The updating is done through a positive regularization parameter and a hinge loss function.
