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The results demonstrated that single cleavage of trastuzumab within the lower hinge severely impaired Fc-mediated immune effector cell function in vitro and resulted in significantly reduced anti-cancer efficacy in vivo.
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The hybrid jacket application on the plastic hinge region of a severely damaged RC bridge column is illustrated in Fig. 4.
However, there was no effect of the prestress on the self-centering capability when the plastic hinge region was damaged severely due to a large lateral displacement.
But this is also problematic because the tympanic bone is attached to the periotic by a flexible "hinge" [21] that would severely hamper transmission of acoustic energy to the periotic bone.
The trunk is generous, with a flat floor, but the hinges intrude into the space, severely limiting the trunk's usefulness.
In our opinion it is effective in the management of severely involved hips with subluxation, incongruence, and hinge abduction.
Reforming water management policy to secure future delivery of environmental flows to the delta hinges on demonstrating the feasibility of delivering environmental water and documenting positive ecological responses of the delta's severely degraded riparian habitat.
FSHD2 patients do not have contractions in either 4q35 array; however, both 4q35 D4Z4 arrays and both 10q26 D4Z4 arrays are severely hypomethylated (<25% CpGs assayed are methylated) due to mutations in the SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing1) gene, or other yet-to-be-identified epigenetic modifiers of D4Z4 repression [ 17, 19, 21].
Goodbye hinge, goodbye foot.
"I was severely depressed.
"I'll change a hinge".
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CEO of Professional Science Editing for Scientists @ prosciediting.com