Sentence examples for hindrances imposed from inspiring English sources
If, however, the p53 site is positioned in nucleosome in the opposite rotational orientation, the p53 binding would be highly unfavorable (practically impossible without unraveling nucleosomal DNA) due to steric hindrances imposed by the core histones.
In a three-dimensional (3-D) environment, cell migration is thought to be additionally impaired by the steric hindrance imposed by the surrounding matrix.
Remarkably, Danusertib lacks the steric hindrance imposed by the substitution of threonine by isoleucine at position 315 and is therefore likely to overcome the highly IM resistance conferring T315I mutation.
This is probably because direct release of FTS from PEG5K-FTS2(L) by intracellular esterases is relatively ineffective due to the steric hindrance imposed by PEG.
The slower adduct reaction is attributable to steric hindrance imposed by the bulky (–C5H11) alkyl tail of HNE (Friedman and Wall 1966).
As the authors point out, however, the lower than expected potency for 3-methyl-2-butenal is related to hindrance imposed by the bulky disubstituted alkene terminus.
An alternative explanation may be that the binding pocket for UblPhospho−Ser65 is distinct from that of ubiquitinPhospho−Ser65 and not accessible due to steric hindrance imposed by the non-phosphorylated Ubl domain.
To determine how the steric hindrance imposed by the L129F mutation affects guanine nucleotide binding, we performed GTP and GDP dissociation assays using purified recombinant wild-type and L129F Rab7.
The lower yields for C-3 arylation can be rationalized by steric hindrance imposed by the aryl substituent in position 2 (compare entries 1 6/Table 4 to entries 1, 5 9, 11/Table 3).
Second, the degree of steric hindrance imposed by the relative density of potential attachment sites per unit length of NM and the limited deformability (stiffness) of the DNA resulting from its persistence length [ 55].
According to the barrier model (Mavrich et al., 2008), the steric hindrance imposed by RNA Pol II induces a compact and regularly spaced nucleosome array within ∼1 kb and progressively dissipates when moving away from the TSS.
