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Thus, when bioactive proteins, such as TNF-α, are able to stably express their activities after binding to polymeric macromolecules, proper attention should be paid to minimize the loss in activity arising from the inhibition of their binding to the receptor molecules due to the steric hindrance posed by the polymeric modifier.
This is probably due to steric hindrance posed by the CH group of the imidazole ring of 25 preventing the heterocycle from approaching closer to the iron.
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Detailed analysis of the curing kinetics at the molecular level shows that Ea dependency on conversion is a combined effect of diffusion of monomers and reaction intermedia, solidification of the reaction medium, "clicking" of chain-like structures, and steric hindrance pose by the hyper-branched molecules.
In 1991 Hazare turned his attention to the ongoing problem of government corruption in Maharashtra as well as at the federal level, particularly because of the hindrance it posed to rural development.
Evidence-based approaches to reduce IPV victimization among conflict-affected women are critical given women's particular vulnerability to IPV, [ 5] the potential long-term physical and mental health sequelae, which have been well-documented, [ 6, 7] and the likely hindrances IPV poses to achieving the Millennium Development Goals [ 8].
The film is set during a time where racial segregation, sexual segregation and educational segregation posed great hindrances to not only women, but especially to women of color.
Oil and grease laden wastewaters pose hindrance to the treatment units and further threaten the receiving water bodies.
Since data unavailability or its limitation can sometimes pose hindrance at many circumstances, the application of hydrogeological model opens the possibility for optimization in such situation.
Indeed, secondary metabolites pose hindrance in binding of different snake venom enzymes to their potential targets; therefore, antidotal effect evoked.
There are indications that introns pose hindrance to rapid gene regulation and are selected against in those genes which require quick adjustment in transcript level to overcome the environmental challenges [ 43].
Cytotoxic effect of Naja naja karachiensis venom may not be overlooked even when antisera administration is late cause of toxic components to the microvasculature and thrombus produced which poses hindrance in access of immunoglobulins to the site of snake bite [ 26, 29, 39].
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