Sentence examples for hinders the binding from inspiring English sources

Regarding how β-catenin mediates these biological effects, results from one of our recently publications have suggested that β-catenin likely hinders the binding of crizotinib to ALK22.

We observed an unexpected effect of a conserved mouse human framework position (L37) that hinders the binding of the humanized scFv to antigen.

In M. musculus AChE, the Y337A (F330A) mutation decreased Ki almost 2700-fold, makitg it comparable to BChE [13], presumably because the side chain of Tyr337 sterically hinders the binding of ethopropazine via an interaction between the aromatic side chain of the residue and the diethylamino-2-isopropyl moiety of the inhibitor.

In cells with DNA damage, increased PRMT1 binding and methylation hinders the binding and methylation by PRMT5.

Another possibility is that the Asp insertion directly hinders the binding or acylation reaction with β-lactams.

This observation was demonstrated by experiments in which activation of α5β1 by chemical agents such as DTT hinders the binding to sCD154.

Therefore Gly to Val change could induce conformational changes in the peptide chain and these changes might hinder the binding of PFN1 to actin.

On the other hand, a rigid binding site may also hinder the binding process as the ion has to perfectly align itself.

The combined four mutations F151S, A152S, F714S, F717S are therefore sufficient to hinder the binding of CaM to hEAG1 (p>0.05) BD-C1 and other auxiliary sites can still be involved in the binding mechanism in a cooperative manner.

One possible explanation is that full-length MUC1 contains a self-aggregation domain that likely contributes to the protein's characteristic clustering and could sterically hinder the binding of ligands to the adjacent region which is the Anti-MUC1* epitope.

With this methodology it is possible to identify fully complementary mAb pairs that would not sterically hinder the binding of each other to the same protein, e.g. for establishing a highly sensitive sandwich ELISA for PrPC and/or PrPSc.