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On the other hand, iPSCs produced by different methods may be not quite identical hindering the evaluation of the impact of different parameters including age.
In this study only two genes evidenced DNA fragments loss, one from each parent, thus hindering the evaluation of potential parental bias.
A limitation of this study is that participants gradually withdrew or dropped out over time, hindering the evaluation of longitudinal variation.
A problem arises in the early stages of a study when time-to-event outcomes are not yet available because of short follow-up, hindering the evaluation of marker effectiveness in terms of survival.
The present study had some limitations, which were also common in several other studies, where the effects of statins and aspirin were evaluated, for example, not being a prospective study or the effect of statins in the serum PSA hindering the evaluation of the influence of this drug in PCa.
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Optimizing too long led to camera saturation and hindered the evaluation of light sheet homogeneity.
This would hinder the evaluation of the light sheet using its image on the camera.
Radiation treatment may also induce irregularities of capsular profile that may hinder the evaluation of extracapsular extension of recurrence [18].
This hinders the evaluation of the coronary artery lumen, eventually causing an overestimation of the degree of stenoses (and thus, a false-positive CT result).
The lack of a 'gold standard' significantly hinders the evaluation of tools' validity.
However, the presence of physiologic uptake in the cerebral cortex may hinder the evaluation of CNS lymphomas.
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