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Ultimately, this would result in cells having a reduced capacity to phosphorylate Rb, thereby, hindering progression through the cell cycle.
Widespread CGI hypermethylation could also result in more aggressive cancers by blocking cellular differentiation or act as a protective mechanism hindering progression by preventing epigenetic adaptation to changing conditions.
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It's this kind of rigid, ineffective reasoning that has hindered progression, but bringing DJs and doctors into the larger conversation is a necessary step towards a functional understanding of drug use in music culture.
A more recent follow-up of some of these patients showed that a meticulously performed brace regimen did hinder progression, with no need for subsequent surgical correction [ 2].
In essence we postulate that lower IGF-1 levels in BBD patients hinder progression to breast cancer in this high risk group, although this finding needs to be replicated in other large investigations.
The nature of integrated assessment adds challenge to measuring communication as an isolated 'fail' criterion, but some schools were able to report that failing to reach competence in this category could – and would – hinder progression.
Explanations for this finding could be that FDG-PET/CT, being a more sensitive method than CT, visualizes the tumor changes in the patients where the treatment induces enough reduction in tumor activity to hinder progression but not enough to reduce size.
However, at the top levels of companies, many women continue to face a glass ceiling hindering their progression up the career ladder.
Antiangiogenic drugs function by inhibiting formation, maintenance, and development of blood vessels and therefore act in hindering the progression of endometriosis [ 77].
The importance of immune function in hindering ependymoma progression and recurrence was also recognized through the study by Donson et al. [111].
We found a slightly lower risk for aggressive compared with non-aggressive tumours, indicating that aspirin might be more influential in hindering the progression than development of prostatic tumours.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com