The continued association of 4-, 5- and 6-sugar polysaccharides with the cellulose surface would likely have the effect of hindering access of EGs to appropriate surface reaction sites, and also reduce the apparent rate of glucose production by being less accessible to enzymes that further degrade them to shorter polysaccharides and, eventually, glucose.
Previous studies on the export performance of Egyptian agricultural commodities have pointed out that the lack of competitive prices is one of the greatest challenges hindering the access of Egypt's agricultural commodities to foreign importing markets (Soliman and Bassiony 2012; Torayeh 2013; Abu Hatab and Hess 2013).
Cabana et al. [ 37] have reported that the aggregation of laccase as cross-linked enzyme aggregates (CLEAs) improved its stability against EDTA by hindering access of EDTA to the Cu II) ions of the protein.
A known drawback of fusion tags is they may interfere with the activity of the candidate protein by sterically hindering access of substrate to the catalytic site, or by causing the candidate to adopt a non-functional, though soluble, conformation [ 76, 77].
This is visual evidence of the so-called small-port behavior hindering access of FFA to the microporous network, which was already demonstrated at the bulk level for many synthetic and natural mordenites.
Increasing the length of the alkyl pendent chain lowered the hydrolysis rates of both hydrolyzable linkages, possibly by hindering the access of water molecules to those sites.
Nucleosomes are generally repressive to transcription, hindering access of the transcriptional apparatus [ 11].
Hemicelluloses and lignin embed cellulose microfibrils in a tight matrix, thus hindering access of cell wall degrading enzymes to the polysaccharides [ 7, 8].
This is likely to be an artefact due to residual tertiary conformation under non-reducing conditions stearically hindering access of streptavidin-HRP to biotinylated residues.
DNA methylation may lead to transcriptional repression by hindering access of transcription factors to promoter regions, although many researchers believe the reverse is true: that gene silencing subsequently leads to DNA methylation.
