Electron-rich (entries 12, 13, 17 and 18), electron-poor (entry 16) and sterically hindered substrates (entries 12 and 14) could all be tolerated and products were isolated in good yields (79 93%) with low levels of diyne homo-coupling.
The commission said Servier and several generic competitors made deals that hindered the entry of generic forms of the drug into European markets.
And in 2011, the commission opened an investigation into whether the American pharmaceutical company Cephalon and the generic maker Teva of Israel hindered the entry of the generic version of modafinil, used for the treatment of certain types of sleeping disorders.
The complex of compound- 7 with urease is stabilized mainly through chelation of phenyl ring which is symmetrically placed between positively charged Ni ions in the active site and hindered the entry of substrate.
In patch 1, for instance, a single-residue substitution of Y499A, expected to eliminate hydrogen bonding between Y499 and R336, significantly interrupted the binding between MERS-CoV RBD and DPP4, as well as hindered viral entry.
I conclude reporting preliminary results form a laboratory experiment showing that reputational mechanisms can be designed to stimulate rather than hindering new entry.
Not only are we subject to high levels of unemployment and poverty, but discrimination on the basis of our faith, gender and ethnic background hinders our entry into the labour market.
The inclusion of a butyl chain of the TBA+ molecule into the cavity of β-CD hinders the entry of the Ni II) complex into the cavity of β-CD.
But some of the provisions it has introduced to the TPP such as those directed at the activities of state-owned enterprises seem designed to hinder Chinese entry.The Chinese government professes an "open" attitude to the TPP.
On the contrary, when the outside temperature is higher than the inside temperature, the gradients of temperature along the access tunnel and the chimney hinder the entry of outside air.
