"Turok has an M rating, which may discourage parents from buying the game and hinder clearance of a commercial airing in shows primarily for children under 12," observed the marketing report.
Increased levels of TGF- β in AD are associated with perivascular deposition of extracellular matrix, which hinders clearance of A β and allows the development of cerebral amyloid angiopathy.
Instead, a large fraction of the cells undergoes necrosis via a positive Ca2+ feedback probably caused by enhanced mitochondrial pore opening, breakdown of the membrane potential and of ATP production, which hinders clearance of Ca2+.
Currently, the ACT's resistance is comparatively low with clinical presentation of hindered artemisinin clearance and a small reduction in artemisinin sensitivity in cultured isolates.
At present, we cannot conclude whether debris accumulates because of hindered lysosomal clearance or by direct antagonistic mechanisms.
Although pharmacologic intervention directed at restoring normal cilia function still has to be developed for commercial use, sinonasal saline lavage is an effective surrogate in removing the deleterious compounds in patients with hindered mucociliary clearance and thus aiding in restoring cilia function.
The resultant dehydration of the airway surface, loss of cilia movement, and accumulation of highly viscous mucous obstructs the airways and hinders clearance, thereby promoting bacterial infection [ 2].
c-di-AMP secreted by L. monocytogenes activates the STING-IRF3 pathway, leading to elevated type I interferon levels that hinder the clearance of intracellular bacteria (Auerbuch et al., 2004; O'Connell et al., 2004).
The endogenous production of IL-10 has been shown to hinder the clearance of many other infectious organisms including Klebsiella pneumoniae, Brucella abortus, Candida albicans, Trypanosoma cruzi and Mycobacterium avium [38] [42].
These findings highlight that alcohol intoxication impairs neutrophil recruitment into infected tissues and the lung and also hinders neutrophil clearance from the lung.
