The 6β-hydroxymethyl group sterically hinders approach of the water molecule as well as restraining the side chain of E166 that facilitates hydrolysis.
"EMA's attitude to redactions should be independently audited to ensure overzealous approaches do not hinder access to important information," Heneghan says.
For fellow New Zealand-born director Regan Hall his own gender has not hindered his approach to his first feature, Fast Girls, a female-centred story about British relay athletes to be released next month before the London olympics.
In the absence of the analyte cation, electrostatic repulsion between the marker anions and the carboxylate groups of the receptor monolayer hindered the approach of the marker anion to the electrode surface and hence hindered its reduction.
Although the PCR-based quantitation requires a less amount of RNA, the high homology of hPGFS with several other genes such as AKR1C3 (two amino acids difference) hindered this approach.
For example, Rubisco, the enzyme that catalyzes the reaction of CO2 into ribulose 1,5-bisphosphate (RuBP), is a prime target for genetic engineering to improve photosynthetic efficiency [ 19], but the locations of rbcL in the chloroplast genome and RbcS in the nuclear genome have hindered this approach [ 20].
Somewhat diminished activity for H6 (compared to H5), when the alkyl group is moved from sulfenyl sulfur to ester oxygen, hinders approach to the carbonyl carbon, suggesting that it may be serving as an electrophile.
The obligate parasitism and long life cycle of plant parasitic nematodes compared to C. elegans, have hindered research approaches aimed at understanding the genes responsible for behavior and parasitism.
Security and instability has hindered systematic approaches to delivering aid.
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic diseases, ignorance of amyloid structure has hindered similar approaches to amyloid disease.
