Large agglomerations of particles can significantly hinder the effects of individual particle size and shape on toxicity [17].
Furthermore, consistent with our previous studies in vivo [9], UV inactivation of the viral nucleic acid hindered the effect of RSV on both NGF upregulation and apoptotic cell death, indicating that the changes observed in the neurotrophin pathways are linked to active viral replication and expression of the viral genome in the respiratory epithelium.
In MDA-MB231 cells, AMD3100, a competitive antagonist of CXCL12, did not modify basal invasiveness, but completely prevented CXCL12-mediated chemoinvasion and also hindered the effect of TSA in HGF-treated cells.
The results showed that during the freezing and thawing period, snow cover hindered the effects of the cumulative temperature on the thickness of the frozen soil layer.
Low-income patients already seem to benefit from current self-management interventions, yet policy-makers should stay vigilant to prevent financial factors from hindering the effects of self-management.
Hypoxia, consistent with an impaired vascular homeostasis, may hinder the angiogenic effect of the upregulated HIF/VEGF pathway in OA.
Metabolic alterations such as the metabolic syndrome, diabetes, or hyperuricemia could hinder the therapeutic effect of PRP.
PRP injection is an autologous treatment derived from the patient's own blood; thus metabolic alterations such as the metabolic syndrome, diabetes, or hyperuricemia could hinder the therapeutic effect of autologous PRP in these patients.
