Silencing of Bmi1 in many other cells such as PC3 and DU145 prostate, MDA-MB 468 breast and RKO colon cancer cell lines had by itself a strong toxic effect (data not shown) that hindered testing sensitization to the drug.
Unfortunately, no ontogenetic study in dogs included the scapula in their measurements, hindering testing the proposed ontogenetic principles in dogs.
In the third paragraph under Results & Discussion, the authors comment that weakness of phylogenetic markers (i.e. their lack of resolving power, illustrated here by rRNA sequence data) can hinder tests (including attempted falsification) of theories.
Unfortunately the paucity of endogenous mRNA targets for SF2/ASF has hindered testing of this hypothesis.
Participants with high school education and above were more likely to report poor health worker attitude as a factor hindering testing for HIV.
Clark and Rutter [ 16] found that motivation and associated disruptive behaviours such as task avoidance, self-stimulation and escape behaviours in children with lower functioning ASD, hindered test performance on the RCPM.
Most of the studies have shown that low risk perception and fear of possible social and individual consequences derived from a positive result hinder HIV testing.
The factors that hinder pharmacogenetic testing and molecular diagnosis include the laborious and time-consuming nature of genotyping, the fidelity of the genotyping results, as well as the cost incurred by the test (5).
According to UNAIDS, criminalisation of HIV transmission may reinforce HIV-related stigma, spread misinformation about HIV, hinder HIV testing and counselling support and, importantly, create a false sense of security by encouraging HIV-negative men to indulge in risky behaviours, believing themselves legally protected from transmission (UNAIDS, 2008).
HIV-related stigma among community members and providers likely hinders HIV testing uptake, but enhanced focus on training providers and encouraging more provider-initiated HIV testing could aid in the effort to de-stigmatize HIV and boost testing uptake [41].
