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These limitations could hinder reliable de novo assembly of MinION reads, which might still result in chimeric consensus sequences that mix reads originating from different viral variants.
As observed in several diseases, different therapeutic interventions may induce a placebo effect that may be strong and hinder reliable clinical evaluations.
Therefore, this may hinder reliable and reproducible measurements of nerve blood flow.
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For compounds hindering reliable measurements by absorption (4-nitrophenol, 4-nitrothiophenol, 2-hydroxybenzoic acid) or fluorescence (BHET) 1 mM final concentrations were also tested.
However, the selectivity of PAD is limited, hindering reliable quantitation in complex matrices, such as plant extracts.
Understanding the process of hybridization in Epidendrum based on morphological characters is a challenging task owing to the high variability of species, which often hinders reliable identification of species in the field [ 38].
Also, the problem of regular power blackouts at MoH hindered reliable access to the central server room leading to unavailability of both the production and training server, and this resulted in intermittent use of the system even at MoH level.
Owing to the sparsity of the protein disease associations derived from Uniprot and GHR, only few of the benchmark miRNA disease associations are of miRNAs or diseases that are present in the input data, hindering reliable prediction performance evaluation.
Several experimental factors of difficult control, such as variation of cell density, hinder a reliable and reproducible application of this assay.
Of particular interests are the closure models for interphase forces which often hinder the reliable prediction of the homogeneous flow regime.
The current formalin-based methods of fixation and processing of tissue for histopathological evaluation hinder the reliable analysis of macromolecules.
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