However, inadequate expression of the immunogenic transgenes has hindered efficacy of the technology and optimization of design and delivery of expression cassettes is vital.
Therefore the practice (although not recommended) of leaving patient-used scopes in enzymatic detergent overnight or over the weekend can serve to increase rather than reduce microbial load and protein buildup, thereby hindering efficacy of the disinfection process.
Organo-mineral complexes may hinder the efficacy of microbial enzymes to degrade organic C [6, 10, 11].
In a recent publication, buyers were admonished to beware of the potential for ingested CAM to cause side effects or hinder the efficacy of conventional therapies [ 33].
This is a serious health risk and may hinder program efficacy, 28 leading to high turnover that can negatively affect the quality of care.
However, Escobar-Páramo et al. (2012) showed that application of antibiotic rifampicin against the host bacteria of a phage decreased the survival of phages in the system and would therefore potentially hinder the efficacy of combined phage and antibiotic treatments.
It could also consider the option of using electronic patient records, which could promote information exchange, though this could also hinder self-efficacy by taking the responsibility for the task away from the patients.
Multidrug resistance (MDR) is a major obstacle that hinders the efficacy of chemotherapy in many human malignancies.
These and the other researchers have emphasized the need to quantify and effectively remove the poorly understood biases that are hindering the efficacy of MI as a measure of coevolution [4] [9].
As human infection with H1N1 viruses continue to increase, so too does the likelihood of antigenic drift and shift leading to generation of novel viruses with potential for higher morbidity and mortality rates and hindering the efficacy of current vaccines.
