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Other studies with comparable series have reported high sensitivities for different methylation markers used alone (Chen et al, 2005; Lenhard et al, 2005; Huang et al, 2007a; Wang and Tang, 2008) or in combination (Leung et al, 2004; Petko et al, 2005; Huang et al, 2007b; Lofton-Day et al, 2008), although a wider application is usually hinder by a limited specificity.
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