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Introducing this bulky side chain would be expected to sterically hinder alignment of the SH2 and kinase domains, resulting in an altered domain packing.
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Owing to their length, PacBio reads provide interesting information to connect other sequences, but this task is made considerably harder by their high error rate, which hinders alignment and similarity detection, both in terms of sensitivity and running time.
On visual inspection of the MR images no subject had focal atrophy of any brain region or movement artefacts which may have hindered alignment into standard space or segmentation into gray or white matter.
While these numbers are high compared to numbers obtained using an agarose based technique, Q clones in HICF projects can arise from the lower overall reproducibility of the fingerprints hindering alignments of such clones in the assembly.
Although well-aligned UDA segments induce the growth of crystallites, the pendant butyrate groups hinder the alignment polyethylene-like chains at the backbone and further depress the overall strength of intermolecular van der Waals interactions.
Instances where a lack of good definitions hindered manual alignment were common, especially when dealing with the FBbt which, as stated above, lacks many definitions.
The inclusion of the divergent Aplousobranchia sequences had hindered the alignment of the 18S rRNA regions corresponding to helices E23_7-E23_7', E23_2-E23_2', E23_7-E23_7' and 49-49'.
The relatively low coverage of the wild sample is probably attributed to the high polymorphism or sequence differences between the wild and the reference (inbred) genome [ 20], which hindered read alignment.
Executives, engineers, and operators often don't understand each other very well, and that lack of alignment can hinder learning.
However, Wang et al. [ 19] used a combination of de novo and alignment methods as the large divergence time between black grouse and domestic chicken (Gallus gallus) used as a reference (~30-40 ~30-40ay hinder sequences fromyaligning properly.
When it comes to delivering oxygen to our breathing bones, the supply is either helped or hindered by our alignment -- this is where Tamar comes in.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com