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The input-dependence of the positive feedback is modulated by the cooperativity parameter q' in the Hill term.
In the Cdc42 cycle, the level of Gβγ affects the rate of activation of Cdc42 (C42) to its active form (C42a) through a cooperative Hill term (k0 term).
The decrease was caused by the increased contribution of the input-dependent Hill term at all positions both front and back.
Given that the value of θ of 0.3, we see that the Hill term will be larger than 0.95 for values of y larger than 1.3 Hz.
As discussed in the 'Materials and methods', the QSSA holds for values of y such that the Hill term can be linearized (y >1.3 Hz).
The expression p represents an input-dependent Hill term in the positive feedback loop; it assumes values between 0 and 1 depending upon the level of input.
Similar(48)
Averaged and normalized data were fit to one or two Hill terms to generate EC50 and Hill coefficient (nH) values.
From the synthetic biology viewpoint, genetic oscillators with only linear, Michaelis-Menten and Hill terms can also be implemented experimentally.
Hills terms the key to this dilemma as the desire to "punch up, not down".
With Hill's term as senator due to expire in March 1837, the legislature also had to fill the six-year term to follow.
In its Sept. 19 decision, the appeals court panel said the department had disregarded the judge's instructions and ordered a recalculation of Mr. Hill's term.
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