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For the hill determination on the community landscape we presented two main approaches (for other possibilities see Section V. in the Electronic Supplementary Material S1): the centrality threshold-based hill determination and the local maxima based hill determination approaches.
However by using local maxima based hill determination methods, it yields overlapping modules over any community landscape.
The centrality threshold-based hill determination approach is appropriate whenever the goal of the analysis is to find modules without overlapping regions.
However, depending on the precise nature of the application, it is possible, or even advised to devise a more elaborate treatment of the subproblems of influence function calculation and community landscape hill determination.
New modularization methods can easily be generated by taking an existing ModuLand modularization protocol, and changing any of its influence function calculation, community landscape generation, or hill determination methods.
Additionally, former methods yielding non-overlapping modules (which can be interpreted as the application of the threshold-based hill determination method) can be upgraded to overlapping modularization methods using the local maxima-based module determination approach of the ModuLand method family (for details see Section IV.4. in the Electronic Supplementary Material S1).
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Here we present two main approaches of hill-determination suitable for the determination of modules.
When my mind wandered during the flight from New York, I could picture one of those impassive delivery boys from a Manhattan Chinese restaurant trying to make it up a nearly perpendicular San Francisco hill, his determination unaffected by breathlessness or leg cramps or the fact that the weird angle has already caused a container of hot-and-sour soup to burst open on his trousers.
Hill's determination to provide community space can still be seen in the shape of the Red Cross site in Southwark (1888), among others.
As demonstrated with Hill constant determination, binomial assay, cooperativity, and sequential analysis, transition of the same dsDNA chain along the channel wall, but at a location 60° different from the last contact, urges dsDNA to revolve forward with a single orientation at 1.75 bp (10.5 bp per turn ÷ 6 ATP = 1.75 bp/ATP).
As demonstrated with Hill constant determination, binomial assay, cooperativity and sequential analysis, transition of the same dsDNA chain along the channel wall, but at a location 60° different from the last contact, urges dsDNA to move forward 1.75 base pairs with each step (10.5 bp/turn ÷ 6ATP = 1.75 bp/ATP).
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